Advanced In-Vitro Systems Mimicking the In-Vivo conditions

Abstract

Our problem is that invitro and invivo systems are hard to compare due to the differences in their complexity, as invitro systems are very simple compared to invivo conditions. Where, there is only one cell type which is cultivated under two-dimensional conditions with an optimized culture medium. In contrast to invivo test where, there is always more than one cell type involved, and cells act in a three-dimensional environment in a dynamic fashion surrounded by different fluids. In case of Invitro tests this condition is considered pathological environment to which cells adapt and respond giving different response than that given to normal environment. Further research is conducted aiming to cross the gap between in vitro and in vivo tests.