Biomaterials Journal

Bioactive Materials for the Future of Dentistry

Tamer Hamdy — Sun, 26 Jan 2025 00:00:00 +0000

The term bioactivity is becoming more common in the fields of medicine and dentistry. Its positive implications often lead to its use in marketing dental restorative materials. However, there is some confusion surrounding the definition of the term, and concerns about its potential overuse have been raised. In response, FDI has decided to publish a Policy Statement regarding the bioactivity of dental restorative materials to clarify the term and outline some precautions for its use in advertising. The background information for this Policy Statement was gathered from current literature, primarily from the PubMed database and various online sources. Bioactive restorative materials should provide beneficial effects that are local, intended, and non-toxic, without interfering with the primary function of the material, which is to replace dental tissue. Three mechanisms of bioactivity for these materials have been identified: purely biological, a combination of biological and chemical, or strictly chemical. When the term bioactivity appears in advertisements or descriptions of dental restorative materials, it is essential to provide scientific evidence—whether from in vitro or in situ studies, and ideally from clinical trials—that outlines the mechanism of action, the duration of the effect (particularly for materials that release antibacterial agents), and the absence of significant adverse biological side effects, such as the development and spread of antimicrobial resistance. Also, it must be proven that the main goal—like fixing the shape and function of damaged or missing teeth—is not harmed. This should be backed up by data from lab tests and studies on patients.

Coatings for Dental Materials: How They Affect Clinical Performance

Rasha Abdelraouf — Sun, 26 Jan 2025 00:00:00 +0000

Contemporary dentistry embraces digital procedures and advanced biomaterials to improve patients' quality of life. As practitioners, we are encouraged to adapt in every aspect of our work, from diagnosis to the creation of prosthetics. The latest biomaterials need to be more damage-tolerant and capable of ensuring longer-lasting results. Consequently, biomimetic replacements, tissue engineering scaffolds, and even cloned teeth could represent the best options for future treatments.

Preparation, characterization, and functional properties of ternary composite nanoparticles for enhanced bioaccessibility and antitumor activity of cannabidiol

zhoushan wu — Sun, 26 Jan 2025 00:00:00 +0000

Cannabidiol (CBD) faces challenges in food and pharmaceutical use due to poor solubility and stability. A novel CBD delivery system using stearic acid-modified Bletilla striata polysaccharides (SA-BSPs) was developed, improving encapsulation and release. Optimal encapsulation efficiency (92.07%) and loading capacity (8.94%) were achieved with a 3:10 CBD to SA-BSPs ratio. The system showed sustained release over a week and strong binding affinity to CB1 receptors. CBD-SA-BSPs copolymer micelles effectively suppressed the proliferation and reduced the viability of MHCC-97H and HCCLM3 cells, particularly the CBD-SA-BSPs (3:10) at a concentration of 20 µg/mL. Compared with the model group, the levels of IL-2, IL-6, and TNF-α in the serum of mice in the drug-administered groups were significantly reduced, suggesting that the drug may exert its anti-hepatocarcinoma effect by regulating the levels of these cytokines. In vivo study results showed that the tumor inhibition rate of 10mg/kg CBD-SA-BSPs (3:10) group was as high as 72.83%, revealing polymer micelles have potential for future therapeutic applications.

Assessment of knowledge, awareness and practices toward the use of 3D technology in planning and performing oral surgeries among dentists: A cross-sectional study

Ghada Salem Awad Ali, Gada Abdul Hafiz Ahmed Ali — Sun, 26 Jan 2025 00:00:00 +0000

Background: The three-dimensional (3D) imaging technology is a contemporary technique that allows for the creation of very clear and detailed 3D pictures of teeth, jaw, and surrounding structure. In oral surgery, it leads to the enhancement of the diagnosis, planning, and implementation of oral surgical procedures. Objectives: Assessment of the knowledge, awareness and practices toward the use of 3D imaging technology in planning and performing oral surgeries among dentists in Libya. Materials and Methods: through January 2025, a cross-sectional questionnaire-based study was employed among dentists with different academic degree (BDS, Master and PhD holder) in Libya, to evaluate the awareness and use of 3D technology among oral surgeons and general dental practitioners (GDPs) utilizing Google Forms and incorporating qualitative questions. Results: Based on the questionnaire responses, it can be concluded that the feedback regarding the use of 3D technology in oral surgeries among oral surgeons and GDPs is favorable. Conclusion: Dentists have a reasonable level of awareness regarding 3D technology in the planning and execution of oral surgeries, which will improve their surgical performance.